单细胞与空转测序相关文章
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当前共找到 41633 篇文献，本页显示第 1 - 20 篇。
| 序号 | 推送日期 | 文章 | 类型 | 简述 | 创新点 | 不足 | 研究目的 | 研究对象 | 领域 | 病种 | 技术 | 模型 | 数据类型 | 样本量 | 平台公司 | 平台技术 | 具体产品 | 平台详情 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 2026-07-26 |
Millepurpan from Astragali Radix binds condensin SMC2 to reverse microglial cell cycle arrest and metabolic reprogramming in neuroinflammation
2026-Sep-15, Bioorganic chemistry
IF:4.5Q1
DOI:10.1016/j.bioorg.2026.110089
PMID:42314597
|
NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 2 | 2026-07-26 |
Advances in Helicobacter pylori-mediated oncogenic signaling pathways in gastric cancer: From pathological evolution to clinical application prospects (Review)
2026-Sep, Oncology letters
IF:2.5Q3
DOI:10.3892/ol.2026.15763
PMID:42500607
|
NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 3 | 2026-02-26 |
Unraveling CD4+ T cell heterogeneity and cell death-associated genes in high-grade serous ovarian cancer: a comprehensive analysis of single-cell RNA and spatial transcriptome sequencing
2026-Aug, Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
IF:2.8Q2
DOI:10.1007/s12094-026-04266-z
PMID:41735641
|
研究论文 | 本研究通过整合单细胞RNA测序和空间转录组学，深入解析了高级别浆液性卵巢癌中CD4+ T细胞的异质性及其与细胞死亡相关基因的关联 | 首次结合单细胞RNA测序与空间转录组学，系统揭示了HGSOC中CD4+ T细胞的异质性，并构建了基于hdWGCNA的预后模型，同时通过共培养实验验证了MAL基因的功能作用 | 研究样本可能有限，且体外共培养实验可能无法完全模拟体内复杂的肿瘤微环境 | 阐明CD4+ T细胞在高级别浆液性卵巢癌进展中的作用，并识别关键的细胞死亡相关基因 | 高级别浆液性卵巢癌患者样本中的CD4+ T细胞 | 数字病理学 | 卵巢癌 | 单细胞RNA测序, 空间转录组学, qPCR, Western blotting | inferCNV, 伪时间轨迹分析, SCENIC转录调控网络, hdWGCNA | 单细胞RNA测序数据, 空间转录组数据 | 独立的高级别浆液性卵巢癌队列 | NA | 单细胞RNA测序, 空间转录组学 | NA | NA |
| 4 | 2026-06-18 |
Early-life manganese overexposure induces dysfunction in energy metabolism conversion that leads to disrupted hippocampal neurogenesis in mouse offspring via METTL3-mediated Cdc25b m6A modification
2026-Aug-01, Journal of hazardous materials
IF:12.2Q1
DOI:10.1016/j.jhazmat.2026.142703
PMID:42302365
|
研究论文 | 早期锰过量暴露通过METTL3介导的Cdc25b m6A修饰，干扰能量代谢转换，导致小鼠后代海马神经发生异常 | 首次揭示早期锰暴露通过能量代谢转换障碍和METTL3介导的Cdc25b mRNA m6A修饰，导致神经干细胞分化受阻的分子机制 | 未明确能量代谢转换障碍与METTL3修饰之间的直接上下游关系，且仅在动物模型和原代细胞中验证 | 探究早期锰暴露引起海马神经发生异常的分子机制，特别是能量代谢转换与Cdc25b mRNA衰变的关系 | C57BL/6小鼠后代及其原代神经干细胞 | 机器学习 | 神经退行性疾病 | 单细胞RNA测序 | NA | 基因表达数据 | 小鼠后代（具体数量未给出）及原代神经干细胞 | 10x Genomics | 单细胞RNA测序 | 10x Chromium | 10x Chromium单细胞3'测序 |
| 5 | 2026-07-26 |
Integrated analyses of the microbiome, metabolome, and spatial transcriptomics reveal sex-dependent bladder vulnerability to chronic inorganic arsenic
2026-Aug-01, Journal of hazardous materials
IF:12.2Q1
DOI:10.1016/j.jhazmat.2026.142653
PMID:42424946
|
NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 6 | 2026-07-26 |
The Single-Cell Atlas Revolution: Integrating Lineage, Space, and Evolution to Decode Animal Biology
2026-Jul-25, DNA and cell biology
IF:2.6Q2
DOI:10.1177/10445498261460199
PMID:42499312
|
NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 7 | 2026-07-26 |
Distinct systemic and gut IgA responses to bacteria of the human upper gastrointestinal tract
2026-Jul-24, Cell reports
IF:7.5Q1
DOI:10.1016/j.celrep.2026.117721
PMID:42497062
|
NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 8 | 2026-07-26 |
ELF3 links kidney function GWAS loci to maladaptive epithelial inflammation
2026-Jul-24, Science advances
IF:11.7Q1
DOI:10.1126/sciadv.aec6741
PMID:42497247
|
NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 9 | 2026-07-26 |
Signaling mechanisms and dynamics governing the myocardial-epicardial fate switch during human cardiogenesis
2026-Jul-24, Science advances
IF:11.7Q1
DOI:10.1126/sciadv.aee5316
PMID:42497271
|
NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 10 | 2026-07-26 |
Periductal Fibroblast Density Defines Lymphocyte Exclusion via a CD44-Dependent Stromal Checkpoint in Pancreatic Cancer
2026-Jul-24, Cancer immunology research
IF:8.1Q1
DOI:10.1158/2326-6066.CIR-25-1481
PMID:42497294
|
NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 11 | 2026-07-26 |
Ophiopogonin D induced Plet1+ macrophage differentiation to treat acute lung injury through blocking the interaction between NCOR1 and PPARγ
2026-Jul-24, International immunopharmacology
IF:4.8Q1
DOI:10.1016/j.intimp.2026.117173
PMID:42497662
|
NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 12 | 2026-07-26 |
Longitudinal zone- and cell type-specific pattern-triggered immune responses in Arabidopsis roots
2026-Jul-24, Developmental cell
IF:10.7Q1
DOI:10.1016/j.devcel.2026.07.002
PMID:42497852
|
NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 13 | 2026-07-26 |
Disease-associated microglia adopt stage-specific phenotypes that regulate T cell fate and immunity in glioma
2026-Jul-24, Immunity
IF:25.5Q1
DOI:10.1016/j.immuni.2026.06.024
PMID:42497861
|
NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 14 | 2026-07-26 |
Targeting DYNC1I1 attenuates Parkinsonian neurodegeneration and α-synuclein accumulation in cellular and mouse models
2026-Jul-24, Brain research bulletin
IF:3.5Q2
|
NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 15 | 2026-07-26 |
Modern approaches to gut microbiome investigation: Sequencing, culturomics, metabolomics, and beyond
2026-Jul-24, Journal of microbiological methods
IF:1.7Q4
DOI:10.1016/j.mimet.2026.107636
PMID:42498043
|
NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 16 | 2026-07-26 |
IL-33 as a component of neutrophil extracellular traps mediates contrast-induced acute kidney injury by promoting ferroptosis in tubular epithelial cells
2026-Jul-24, Kidney international
IF:14.8Q1
DOI:10.1016/j.kint.2026.06.039
PMID:42498057
|
NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 17 | 2026-07-26 |
IGF2BP1 regulates the malignant progression of intrahepatic cholangiocarcinoma by recognizing the m6A modification of FN1
2026-Jul-24, Arab journal of gastroenterology : the official publication of the Pan-Arab Association of Gastroenterology
IF:1.1Q4
DOI:10.1016/j.ajg.2026.07.005
PMID:42498553
|
NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 18 | 2026-07-26 |
Molecular mechanisms of heavy metal-induced cancer: Insights from animal models and human implications
2026-Jul-24, Toxicology and industrial health
IF:1.7Q4
DOI:10.1177/07482337261469287
PMID:42498637
|
NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 19 | 2026-07-26 |
FOSL2-driven SASP in endometrial stroma promotes the inflammation of endometriosis
2026-Jul-24, npj aging
IF:4.1Q2
DOI:10.1038/s41514-026-00447-w
PMID:42498708
|
NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 20 | 2026-07-26 |
PLIN2-PGAM5-regulated lipid droplet-mitochondria contacts drive microglial neuroinflammation after spinal cord injury via fatty acid metabolic reprogramming
2026-Jul-24, Cell death and differentiation
IF:13.7Q1
DOI:10.1038/s41418-026-01815-5
PMID:42498720
|
NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |