本数据库通过收集和整理最新科研文献信息而得,供了解领域前沿进展之用。数据源自 PubMed Data ,每日自动更新(使用关键词“['single-cell sequencing', 'single-cell RNA sequencing', 'single-cell transcriptomics', 'single-cell RNA-seq', 'single-cell transcriptome', 'scRNA-seq', 'spatial transcriptomics']”过滤),已收录文献数量参见 统计表格。表格内容由 GPT 自动整理,可能存在错误或遗漏,请使用时务必注意核实!
如有建议或合作意向,欢迎联系 linlin.yan(AT)bioinfo.app 或 微信 yanlinlin82。本项目遵循 MIT 许可 发布,欢迎下载 源码 自行修改使用。如觉得不错,还请不吝 给我打赏,你的支持是我继续创新的重要动力!


除通过在线浏览外,为方便用户离线查阅,本站也提供 付费下载(定价19.9元)。之所以考虑收费,是因为批量扫描这些文献并整理也是有一定成本的,还请理解并多多支持。本站数据会持续更新,而仅需一次付费,未来就可以随时重新下载到最新版本数据。
| 序号 | 推送日期 | 文章 | 类型 | 简述 | 创新点 | 不足 | 研究目的 | 研究对象 | 领域 | 病种 | 技术 | 模型 | 数据类型 | 样本量 | 平台公司 | 平台技术 | 具体产品 | 平台详情 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 261 | 2026-07-26 |
Disease-associated microglia adopt stage-specific phenotypes that regulate T cell fate and immunity in glioma
2026-Jul-24, Immunity
IF:25.5Q1
DOI:10.1016/j.immuni.2026.06.024
PMID:42497861
|
NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 262 | 2026-07-26 |
Targeting DYNC1I1 attenuates Parkinsonian neurodegeneration and α-synuclein accumulation in cellular and mouse models
2026-Jul-24, Brain research bulletin
IF:3.5Q2
|
NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 263 | 2026-07-26 |
Modern approaches to gut microbiome investigation: Sequencing, culturomics, metabolomics, and beyond
2026-Jul-24, Journal of microbiological methods
IF:1.7Q4
DOI:10.1016/j.mimet.2026.107636
PMID:42498043
|
NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 264 | 2026-07-26 |
IL-33 as a component of neutrophil extracellular traps mediates contrast-induced acute kidney injury by promoting ferroptosis in tubular epithelial cells
2026-Jul-24, Kidney international
IF:14.8Q1
DOI:10.1016/j.kint.2026.06.039
PMID:42498057
|
NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 265 | 2026-07-26 |
IGF2BP1 regulates the malignant progression of intrahepatic cholangiocarcinoma by recognizing the m6A modification of FN1
2026-Jul-24, Arab journal of gastroenterology : the official publication of the Pan-Arab Association of Gastroenterology
IF:1.1Q4
DOI:10.1016/j.ajg.2026.07.005
PMID:42498553
|
NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 266 | 2026-07-26 |
Molecular mechanisms of heavy metal-induced cancer: Insights from animal models and human implications
2026-Jul-24, Toxicology and industrial health
IF:1.7Q4
DOI:10.1177/07482337261469287
PMID:42498637
|
NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 267 | 2026-07-26 |
FOSL2-driven SASP in endometrial stroma promotes the inflammation of endometriosis
2026-Jul-24, npj aging
IF:4.1Q2
DOI:10.1038/s41514-026-00447-w
PMID:42498708
|
NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 268 | 2026-07-26 |
PLIN2-PGAM5-regulated lipid droplet-mitochondria contacts drive microglial neuroinflammation after spinal cord injury via fatty acid metabolic reprogramming
2026-Jul-24, Cell death and differentiation
IF:13.7Q1
DOI:10.1038/s41418-026-01815-5
PMID:42498720
|
NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 269 | 2026-07-26 |
Time-dependent effects of rapid-acting antidepressants in iPSC-derived neurons from treatment-resistant depression and healthy volunteers
2026-Jul-24, Molecular psychiatry
IF:9.6Q1
DOI:10.1038/s41380-026-03768-0
PMID:42498781
|
NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 270 | 2026-07-26 |
Full-length single-cell spatial transcriptomics reveals spatial and cell-type-specific transcript isoforms in the primate brain
2026-Jul-24, Nature methods
IF:36.1Q1
DOI:10.1038/s41592-026-03174-y
PMID:42498883
|
NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 271 | 2026-07-26 |
Integrated analysis of scRNA-seq and TCR-seq on T cells in aneurysmal subarachnoid hemorrhage: A descriptive, hypothesis-generating case study
2026-Jul-24, Medicine
IF:1.3Q2
DOI:10.1097/MD.0000000000049817
PMID:42499108
|
NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 272 | 2026-07-26 |
Mouse MFGE8high Skeletal Stem Cells Drive Osteogenesis via Matrix Mechanics
2026-Jul-24, Journal of dental research
IF:5.7Q1
DOI:10.1177/00220345261466239
PMID:42499209
|
NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 273 | 2026-07-25 |
Single-cell resolution of skeletal muscle aging: Current paradigms and perspectives
2026-Jul-23, Ageing research reviews
IF:12.5Q1
DOI:10.1016/j.arr.2026.103272
PMID:42492807
|
NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 274 | 2026-07-26 |
PFOA promotes PMAIP1-MCL1 apoptotic vulnerability within a BHLHE41-associated macrophage regulatory architecture in atherosclerosis
2026-Jul-22, Chemico-biological interactions
IF:4.7Q1
DOI:10.1016/j.cbi.2026.112265
PMID:42486287
|
NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 275 | 2026-07-26 |
Robust and generalizable CNV detection for single-cell sequencing assays
2026-Jul-17, Nucleic acids research
IF:16.6Q1
DOI:10.1093/nar/gkag636
PMID:42500822
|
NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 276 | 2026-05-08 |
Predictive control of human pancreatic cell fate using a digital model of in vitro differentiation
2026-Jul-16, bioRxiv : the preprint server for biology
DOI:10.64898/2026.04.27.721124
PMID:42094425
|
研究论文 | 构建胰腺胰岛分化的数字孪生模型以预测细胞命运 | 首次整合时间序列多组学数据构建预测性数字孪生模型,能够解析谱系轨迹并推断细胞命运决定的因果调控因子 | 未提及具体局限性 | 建立预测性框架以解析细胞命运特化和谱系轨迹的调控决定因素 | 人诱导多能干细胞分化为胰腺胰岛类器官的过程 | 机器学习 | 糖尿病 | 单细胞测序 | 数字孪生模型 | 时间序列多组学数据 | NA | NA | 单细胞多组学 | NA | NA |
| 277 | 2026-07-15 |
The perineurium integrates leptin with its sympathetic outflow to protect against obesity
2026-Jul, Nature metabolism
IF:18.9Q1
DOI:10.1038/s42255-026-01555-3
PMID:42443582
|
研究论文 | 使用小鼠交感神经节的单细胞RNA测序,发现神经束膜细胞整合瘦素与交感流出以抵抗肥胖,揭示了瘦素作用中外周调控的新机制 | 首次发现神经束膜细胞同时表达瘦素受体和β-肾上腺素能受体,并揭示其在调节能量消耗和体重中的关键作用 | 研究主要基于小鼠模型,临床观察仅为相关性分析,且未排除其他细胞类型在过程中的贡献 | 探究瘦素外周传入与交感神经传出平衡的调控机制 | 小鼠交感神经节的神经束膜细胞、脂肪组织中的交感神经元束 | 单细胞转录组学 | 肥胖 | 单细胞RNA测序 | NA | 单细胞转录组数据 | 小鼠交感神经节样本 | 10x Genomics | 单细胞RNA-seq | 10x Chromium | 10x Chromium Single Cell 3' |
| 278 | 2026-07-25 |
Developing an epithelial signature for prognosis of papillary thyroid carcinoma
2026-Jul-01, Endocrine-related cancer
IF:4.1Q2
DOI:10.1530/ERC-25-0515
PMID:42447050
|
NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 279 | 2026-07-26 |
Integrated Proteogenomics and Single-Cell Transcriptomics Prioritize Putative Protective Plasma Proteins for Hidradenitis Suppurativa
2026-Jul, Experimental dermatology
IF:3.5Q1
DOI:10.1111/exd.70332
PMID:42499219
|
NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 280 | 2026-07-26 |
A nucleolar stress gene signature enables quantitative scoring across multi-omics contexts
2026-06-29, Communications biology
IF:5.2Q1
DOI:10.1038/s42003-026-10528-x
PMID:42373768
|
NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |