单细胞与空转测序相关文章
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当前共找到 7432 篇文献，本页显示第 101 - 120 篇。
| 序号 | 推送日期 | 文章 | 类型 | 简述 | 创新点 | 不足 | 研究目的 | 研究对象 | 领域 | 病种 | 技术 | 模型 | 数据类型 | 样本量 | 平台公司 | 平台技术 | 具体产品 | 平台详情 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 101 | 2026-07-25 |
Not all reference samples are equal in single-cell transcriptomics of human kidney tissue
2026-Jul-22, JCI insight
IF:6.3Q1
DOI:10.1172/jci.insight.204385
PMID:42160485
|
NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 102 | 2026-07-25 |
p21-senescent cells drive pancreatic islet dysfunction through targetable paracrine signaling in type 2 diabetes
2026-Jul-22, JCI insight
IF:6.3Q1
DOI:10.1172/jci.insight.197310
PMID:42262869
|
NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 103 | 2026-07-25 |
A loss-of-function polymorphism in the propeptide of lysyl oxidase exacerbates atherosclerosis
2026-Jul-22, JCI insight
IF:6.3Q1
DOI:10.1172/jci.insight.201535
PMID:42484377
|
NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 104 | 2026-07-25 |
GZMK-expressing tissue-resident memory CD8+ T cells participate in human intestinal acute graft-versus-host disease
2026-Jul-22, JCI insight
IF:6.3Q1
DOI:10.1172/jci.insight.199156
PMID:42484374
|
NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 105 | 2026-07-25 |
SC-framework: A robust and FAIR semi-interactive environment for single-cell resolution datasets
2026-Jul-17, iScience
IF:4.6Q1
DOI:10.1016/j.isci.2026.116631
PMID:42491580
|
NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 106 | 2026-07-25 |
Generation of a distal lung cancer organoid model using oncogenic ret-expressing induced pluripotent stem cells
2026-Jul-17, iScience
IF:4.6Q1
DOI:10.1016/j.isci.2026.116554
PMID:42491694
|
NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 107 | 2026-07-25 |
Immune-epithelial crosstalk governs immune checkpoint inhibitor efficacy in colorectal cancer
2026-Jul-17, iScience
IF:4.6Q1
DOI:10.1016/j.isci.2026.116544
PMID:42491875
|
NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 108 | 2026-07-25 |
Integrated Transcriptomic, In Silico, and In Vitro Characterization of lncRNA ENST00000615487.1 Reveals Epithelial-Specific Expression, Differential Subcellular Distribution Between Normal and Colorectal Cancer Cells, and Potential Regulatory Functions
2026-Jul-17, Non-coding RNA
IF:3.6Q2
DOI:10.3390/ncrna12040024
PMID:42496243
|
NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 109 | 2026-07-25 |
Role of Abca7-related microglial responses in linking type 2 diabetes mellitus to Alzheimer's disease progression: Evidence from single-cell transcriptomic analysis and experimental validation in animal and cell models
2026-Jul-16, European journal of pharmacology
IF:4.2Q1
DOI:10.1016/j.ejphar.2026.179152
PMID:42463036
|
NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 110 | 2026-07-25 |
Integrated single-cell and network analysis identifies SLAMF7 as a secretory mediator of the joint-lung axis in rheumatoid arthritis-associated interstitial lung disease targetable by Tanshinone IIA
2026-Jul-15, Phytomedicine : international journal of phytotherapy and phytopharmacology
IF:6.7Q1
DOI:10.1016/j.phymed.2026.158583
PMID:42492262
|
NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 111 | 2026-07-25 |
Tooth development, replacement and regeneration
2026-Jul-15, Development (Cambridge, England)
DOI:10.1242/dev.205531
PMID:42496585
|
NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 112 | 2026-07-25 |
SRY-Box 9-Driven Spasmolytic Polypeptide-Expressing Metaplasia Cell Lineage Plasticity Is a Potential Therapeutic Target That Mitigates Risk of Metaplastic Progression to Gastric Cancer
2026-Jul-14, Gastroenterology
IF:25.7Q1
DOI:10.1053/j.gastro.2026.06.024
PMID:42448241
|
NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 113 | 2026-07-25 |
Cross-layer multiomic and digital pathology analysis identifies a malignant keratinization state linked to immune exclusion in cervical squamous carcinoma
2026-Jul-09, Journal of translational medicine
IF:6.1Q1
DOI:10.1186/s12967-026-08567-3
PMID:42426811
|
NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 114 | 2026-06-23 |
PanKbase Integrated Single-Cell Map: A Comprehensive Atlas of Human Pancreatic Islets
2026-Jul-07, bioRxiv : the preprint server for biology
DOI:10.64898/2026.06.02.729719
PMID:42327171
|
research paper | 构建了一个统一的人类胰腺胰岛单细胞图谱，整合来自多个来源的数据以研究1型糖尿病 | 整合了来自140名捐赠者、涵盖五种表型组的191个高质量测序数据，包括实验扰动样本（如SARS-CoV-2感染和促炎细胞因子暴露），并提供了公开访问的在线平台 | 未明确说明，但可能受限于公开数据的异质性和整合过程中对变量的控制 | 创建统一的单细胞RNA测序图谱以支持糖尿病病理生理学研究 | 人类分离胰腺胰岛组织及其单细胞数据 | machine learning | type 1 diabetes, type 2 diabetes | scRNA-seq | NA | 图像，文本 | 140名捐赠者中的191个高质量测序样本，包含448,935个细胞 | NA | single-cell RNA-seq | NA | NA |
| 115 | 2026-07-25 |
Single-cell transcriptomics identifies CD36 as a negative regulator of osteogenic differentiation in murine osteoporosis
2026-Jul-07, Joint bone spine
IF:3.8Q1
DOI:10.1016/j.jbspin.2026.106096
PMID:42413604
|
NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 116 | 2026-07-25 |
E2F1 Drives Endothelial Arterial Programming in Pulmonary Arterial Hypertension
2026-Jul-07, bioRxiv : the preprint server for biology
DOI:10.64898/2026.07.02.736230
PMID:42465492
|
NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 117 | 2026-07-25 |
Expression of Concern: Advances and challenges in single-cell RNA sequencing data analysis: a comprehensive review
2026-07-03, Briefings in bioinformatics
IF:6.8Q1
DOI:10.1093/bib/bbag433
PMID:42490141
|
NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 118 | 2026-07-10 |
SpatialPEFT: a parameter-efficient fine-tuning framework for spatial transcriptomics foundation models
2026-Jul-02, Bioinformatics (Oxford, England)
DOI:10.1093/bioinformatics/btag503
PMID:42421217
|
研究论文 | SpatialPEFT是一个统一的参数高效微调框架，可在单张16 GB消费级GPU上实现大规模空间转录组基础模型（高达14亿参数）的鲁棒适应 | 集成低秩适应（LoRA）、梯度检查点和空间感知适配器，峰值VRAM减少超过87%，同时显著提升下游空间注释准确性 | NA | 开发参数高效微调框架以适应性调整大规模空间转录组基础模型 | 空间转录组基础模型 | 数字病理 | NA | 空间转录组学 | 低秩适应（LoRA） | 空间转录组数据 | NA | NA | 空间转录组学 | NA | NA |
| 119 | 2026-07-10 |
Structural-information guided fusion for spatial domain identification from spatial transcriptomics
2026-Jul-02, Bioinformatics (Oxford, England)
DOI:10.1093/bioinformatics/btag508
PMID:42423290
|
研究论文 | 提出了一种名为SGFST的框架，通过整合空间图和信号图，并利用双分支图卷积网络与注意力融合，从空间转录组数据中识别空间域 | 首次将空间图与信号图融合，并通过双分支图卷积网络和注意力机制捕捉互补的空间和功能信息，同时联合优化贝叶斯个性化排序损失、零膨胀负二项损失和距离结构信息约束，以保留局部邻域连续性和全局拓扑一致性 | 未明确提及，但可能依赖于高质量的空间转录组数据，且对大规模数据集的扩展性有待验证 | 从空间转录组数据中准确识别空间域，以理解组织结构和病理机制 | 空间转录组数据集中的空间域 | 机器学习 | NA | 空间转录组学 | 图卷积网络 (GCN) | 空间转录组数据 | 多个数据集（未具体说明数量） | NA | 空间转录组学 | NA | NA |
| 120 | 2026-07-25 |
Odon: an ultra-fast viewer for spatial proteomics
2026-Jul-02, Bioinformatics (Oxford, England)
DOI:10.1093/bioinformatics/btag514
PMID:42435412
|
NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |