单细胞与空转测序相关文章
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当前共找到 7432 篇文献，本页显示第 61 - 80 篇。
| 序号 | 推送日期 | 文章 | 类型 | 简述 | 创新点 | 不足 | 研究目的 | 研究对象 | 领域 | 病种 | 技术 | 模型 | 数据类型 | 样本量 | 平台公司 | 平台技术 | 具体产品 | 平台详情 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 61 | 2026-06-14 |
The RELA-FTH1 axis in senescent cancer-associated fibroblasts creates a stromal iron sink that drives ferroptosis resistance and therapy failure across solid malignant tumors
2026-Sep, Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy
IF:15.8Q1
DOI:10.1016/j.drup.2026.101415
PMID:42284685
|
研究论文 | 揭示衰老癌症相关成纤维细胞通过RELA-FTH1轴形成基质铁池，促进铁死亡抵抗和实体恶性肿瘤治疗失败 | 首次阐明senCAFs通过RELA-FTH1轴建立基质铁池，通过螯合微环境铁离子保护肿瘤细胞免于铁死亡，且该机制在多种实体瘤中具有泛癌普适性 | 研究主要依赖细胞系和异种移植模型，缺乏患者来源样本的验证，且未深入探究senCAFs与免疫细胞间的相互作用 | 研究衰老癌症相关成纤维细胞如何通过铁代谢重编程驱动实体瘤治疗抵抗 | 31种实体恶性肿瘤中的senCAFs及邻近肿瘤细胞 | 数字病理学 | 肺癌、前列腺癌、心血管疾病、老年病等（泛实体瘤） | 单细胞RNA测序、空间转录组学、条件培养基实验、Transwell共培养、铁橙探针检测、基因干扰（shRNA/siRNA）、药物抑制、皮下异种移植模型 | LASSO/Cox回归模型 | 单细胞RNA测序数据、空间转录组数据、临床预后数据 | 6个单细胞RNA测序数据集（共431,513个细胞）及TCGA独立队列 | 10x Genomics, Illumina | 单细胞RNA测序, 空间转录组学 | 10x Chromium, Illumina NovaSeq | 10x Chromium Single Cell 3'测序, 空间转录组学FFPE样本分析 |
| 62 | 2026-07-25 |
Single-cell transcriptomic analysis of endometrium pre-receptivity and receptivity stages in porcine
2026-Sep, Reproductive biology
IF:2.5Q3
DOI:10.1016/j.repbio.2026.101219
PMID:42139939
|
NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 63 | 2026-07-25 |
Understanding adipocyte heterogeneity across species, depot, and disease
2026-Aug-26, Biochemical Society transactions
IF:3.8Q2
DOI:10.1042/BST20250327
PMID:42495785
|
NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 64 | 2026-07-25 |
[A multi-level study of androgen deprivation therapy on the immune microenvironment in prostate cancer]
2026-Aug-18, Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences
PMID:42493444
|
NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 65 | 2026-07-25 |
Multi-omics identification of aging-related diagnostic genes and therapeutic targets in renal fibrosis
2026-Aug-15, Clinica chimica acta; international journal of clinical chemistry
DOI:10.1016/j.cca.2026.121058
PMID:42102994
|
NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 66 | 2026-07-25 |
Single-cell transcriptomic insights into lipoprotein transport in yolk sac membrane endodermal epithelial cells of chicken embryos
2026-Aug, Poultry science
IF:3.8Q1
DOI:10.1016/j.psj.2026.106950
PMID:42102753
|
NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 67 | 2026-07-25 |
Decoding immunotherapy resistance in multiple myeloma: genetic insights and approaches to counter resistance
2026-Aug, Science China. Life sciences
DOI:10.1007/s11427-025-3227-0
PMID:42101566
|
NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 68 | 2026-07-25 |
Innovative technologies and future perspectives in tumor microbiomics
2026-Aug, Science China. Life sciences
DOI:10.1007/s11427-025-3202-x
PMID:42132991
|
NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 69 | 2026-07-25 |
Comparison of Sertoli cells in duck testes pre- and post-sexual maturation
2026-Aug, Poultry science
IF:3.8Q1
DOI:10.1016/j.psj.2026.107021
PMID:42190478
|
NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 70 | 2026-07-25 |
The neurotoxicity of Chlorantraniliprole to Helicoverpa armigera larvae
2026-Aug, Pesticide biochemistry and physiology
IF:4.2Q1
DOI:10.1016/j.pestbp.2026.107206
PMID:42493017
|
NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 71 | 2026-07-25 |
Renal Phosphate Reabsorption in Humans Depends on at Least Three Distinct Transporters Unlike in Mice
2026-Aug, Acta physiologica (Oxford, England)
DOI:10.1111/apha.70271
PMID:42494142
|
NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 72 | 2026-07-25 |
An organotypic ectocervix mucosa model to study host-pathogen interaction of sexually transmitted infections
2026-Aug, Materials today. Bio
DOI:10.1016/j.mtbio.2026.103454
PMID:42494413
|
NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 73 | 2026-07-25 |
Integrative machine learning and multi-omics identify a centromere gene signature and validate B3GALT4 as a tumor suppressor in osteosarcoma
2026-Aug, Journal of bone oncology
IF:3.1Q2
DOI:10.1016/j.jbo.2026.100787
PMID:42494653
|
NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 74 | 2026-07-25 |
Single-cell analysis of the epigenome and 3D chromatin architecture in the human retina
2026-Jul-24, Science advances
IF:11.7Q1
DOI:10.1126/sciadv.adv9162
PMID:42490430
|
NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 75 | 2026-07-25 |
Mechanisms and therapeutic targets in distant metastasis of lung adenocarcinoma
2026-Jul-24, Signal transduction and targeted therapy
IF:40.8Q1
DOI:10.1038/s41392-026-02817-y
PMID:42493498
|
NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 76 | 2026-07-25 |
Single-Cell Profiling Reveals Stromal-Immune Remodeling in HNSCC After TPF-Based Neoadjuvant Chemotherapy
2026-Jul-24, Head & neck
DOI:10.1002/hed.70408
PMID:42495797
|
NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 77 | 2026-07-25 |
Single-cell transcriptomics reveal PD-1-loss-driven immune dysregulation of pulmonary lymphocytes during early Mycobacterium tuberculosis infection
2026-Jul-24, Microbiology spectrum
IF:3.7Q2
DOI:10.1128/spectrum.01199-26
PMID:42496156
|
NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 78 | 2026-07-25 |
Continuous modeling of primate embryogenesis from totipotency to early organogenesis
2026-Jul-23, Cell
IF:45.5Q1
DOI:10.1016/j.cell.2026.05.023
PMID:42269606
|
NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 79 | 2026-07-25 |
Rapid recovery and functional resilience of bone marrow function post B-cell acute lymphoblastic leukemia
2026-07-23, Haematologica
IF:8.2Q1
DOI:10.3324/haematol.2025.300439
PMID:42489070
|
NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 80 | 2026-07-25 |
Single-Cell RNA sequencing reveals clonally-expanded CD4+ tissue-resident memory T cells in Histidyl-tRNA Synthetase-induced myositis
2026-Jul-23, JCI insight
IF:6.3Q1
DOI:10.1172/jci.insight.208009
PMID:42490151
|
NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |