单细胞与空转测序相关文章
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当前共找到 9459 篇文献，本页显示第 3601 - 3620 篇。
| 序号 | 推送日期 | 文章 | 类型 | 简述 | 创新点 | 不足 | 研究目的 | 研究对象 | 领域 | 病种 | 技术 | 模型 | 数据类型 | 样本量 | 平台公司 | 平台技术 | 具体产品 | 平台详情 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 3601 | 2026-07-26 |
Epigenetic Modulators and Immunotherapy in Malignant Melanoma
2026, Oncology research
IF:2.0Q3
DOI:10.32604/or.2026.072349
PMID:42500571
|
NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 3602 | 2026-07-26 |
Tumour-Derived sEVs Promote Triple-Negative Breast Cancer Progression Associated with HAVCR2 Upregulation in Macrophages
2026, Oncology research
IF:2.0Q3
DOI:10.32604/or.2026.079137
PMID:42500577
|
NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 3603 | 2026-07-26 |
Single-cell sequencing uncovers clonal dynamics profiles and therapeutic resistance biomarkers in relapsed and refractory peripheral T-cell lymphoma
2026, Frontiers in immunology
IF:5.7Q1
DOI:10.3389/fimmu.2026.1790664
PMID:42500655
|
NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 3604 | 2026-07-26 |
Spatial transcriptomics reveals molecular differences associated with malignant transformation in oral epithelial dysplasia
2026, Frontiers in immunology
IF:5.7Q1
DOI:10.3389/fimmu.2026.1817749
PMID:42500650
|
NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 3605 | 2026-07-26 |
Single-cell and spatial profiling reveal an IL-10-associated iCAF-M2 macrophage communication axis in high-grade serous ovarian cancer ascites
2026, Frontiers in immunology
IF:5.7Q1
DOI:10.3389/fimmu.2026.1790912
PMID:42500684
|
NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 3606 | 2026-07-05 |
Single-cell eQTL and Mendelian randomization analyses of shared genetic architecture in major depressive disorder and schizophrenia
2026-Nov-15, Journal of affective disorders
IF:4.9Q1
DOI:10.1016/j.jad.2026.122166
PMID:42372879
|
研究论文 | 通过单细胞eQTL和孟德尔随机化分析，揭示精神分裂症和重度抑郁症共享的细胞类型特异性遗传机制 | 首次整合单细胞eQTL数据与大规模GWAS统计，通过孟德尔随机化和贝叶斯共定位分析，在八种主要脑细胞类型中鉴定共享候选基因 | 未明确提及，但可能包括样本规模、细胞类型覆盖度及因果机制验证不足 | 阐明精神分裂症和重度抑郁症共有的细胞类型特异性遗传机制 | 精神分裂症和重度抑郁症患者脑组织的八种主要细胞类型 | 自然语言处理 | 精神分裂症, 重度抑郁症 | 单细胞eQTL, GWAS, 孟德尔随机化 | NA | 单细胞RNA测序数据, GWAS汇总统计 | 未明确提及 | NA | 单细胞RNA测序 | NA | NA |
| 3607 | 2026-06-14 |
The RELA-FTH1 axis in senescent cancer-associated fibroblasts creates a stromal iron sink that drives ferroptosis resistance and therapy failure across solid malignant tumors
2026-Sep, Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy
IF:15.8Q1
DOI:10.1016/j.drup.2026.101415
PMID:42284685
|
研究论文 | 揭示衰老癌症相关成纤维细胞通过RELA-FTH1轴形成基质铁池，促进铁死亡抵抗和实体恶性肿瘤治疗失败 | 首次阐明senCAFs通过RELA-FTH1轴建立基质铁池，通过螯合微环境铁离子保护肿瘤细胞免于铁死亡，且该机制在多种实体瘤中具有泛癌普适性 | 研究主要依赖细胞系和异种移植模型，缺乏患者来源样本的验证，且未深入探究senCAFs与免疫细胞间的相互作用 | 研究衰老癌症相关成纤维细胞如何通过铁代谢重编程驱动实体瘤治疗抵抗 | 31种实体恶性肿瘤中的senCAFs及邻近肿瘤细胞 | 数字病理学 | 肺癌、前列腺癌、心血管疾病、老年病等（泛实体瘤） | 单细胞RNA测序、空间转录组学、条件培养基实验、Transwell共培养、铁橙探针检测、基因干扰（shRNA/siRNA）、药物抑制、皮下异种移植模型 | LASSO/Cox回归模型 | 单细胞RNA测序数据、空间转录组数据、临床预后数据 | 6个单细胞RNA测序数据集（共431,513个细胞）及TCGA独立队列 | 10x Genomics, Illumina | 单细胞RNA测序, 空间转录组学 | 10x Chromium, Illumina NovaSeq | 10x Chromium Single Cell 3'测序, 空间转录组学FFPE样本分析 |
| 3608 | 2026-07-25 |
Single-cell transcriptomic analysis of endometrium pre-receptivity and receptivity stages in porcine
2026-Sep, Reproductive biology
IF:2.5Q3
DOI:10.1016/j.repbio.2026.101219
PMID:42139939
|
NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 3609 | 2026-07-25 |
Understanding adipocyte heterogeneity across species, depot, and disease
2026-Aug-26, Biochemical Society transactions
IF:3.8Q2
DOI:10.1042/BST20250327
PMID:42495785
|
NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 3610 | 2026-07-25 |
Multi-omics identification of aging-related diagnostic genes and therapeutic targets in renal fibrosis
2026-Aug-15, Clinica chimica acta; international journal of clinical chemistry
DOI:10.1016/j.cca.2026.121058
PMID:42102994
|
NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 3611 | 2026-07-25 |
Single-cell transcriptomic insights into lipoprotein transport in yolk sac membrane endodermal epithelial cells of chicken embryos
2026-Aug, Poultry science
IF:3.8Q1
DOI:10.1016/j.psj.2026.106950
PMID:42102753
|
NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 3612 | 2026-07-25 |
Decoding immunotherapy resistance in multiple myeloma: genetic insights and approaches to counter resistance
2026-Aug, Science China. Life sciences
DOI:10.1007/s11427-025-3227-0
PMID:42101566
|
NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 3613 | 2026-07-25 |
Innovative technologies and future perspectives in tumor microbiomics
2026-Aug, Science China. Life sciences
DOI:10.1007/s11427-025-3202-x
PMID:42132991
|
NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 3614 | 2026-07-25 |
Comparison of Sertoli cells in duck testes pre- and post-sexual maturation
2026-Aug, Poultry science
IF:3.8Q1
DOI:10.1016/j.psj.2026.107021
PMID:42190478
|
NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 3615 | 2026-07-25 |
The neurotoxicity of Chlorantraniliprole to Helicoverpa armigera larvae
2026-Aug, Pesticide biochemistry and physiology
IF:4.2Q1
DOI:10.1016/j.pestbp.2026.107206
PMID:42493017
|
NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 3616 | 2026-07-25 |
An organotypic ectocervix mucosa model to study host-pathogen interaction of sexually transmitted infections
2026-Aug, Materials today. Bio
DOI:10.1016/j.mtbio.2026.103454
PMID:42494413
|
NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 3617 | 2026-07-25 |
Integrative machine learning and multi-omics identify a centromere gene signature and validate B3GALT4 as a tumor suppressor in osteosarcoma
2026-Aug, Journal of bone oncology
IF:3.1Q2
DOI:10.1016/j.jbo.2026.100787
PMID:42494653
|
NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 3618 | 2026-07-25 |
Single-Cell Profiling Reveals Stromal-Immune Remodeling in HNSCC After TPF-Based Neoadjuvant Chemotherapy
2026-Jul-24, Head & neck
DOI:10.1002/hed.70408
PMID:42495797
|
NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 3619 | 2026-07-25 |
Continuous modeling of primate embryogenesis from totipotency to early organogenesis
2026-Jul-23, Cell
IF:45.5Q1
DOI:10.1016/j.cell.2026.05.023
PMID:42269606
|
NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 3620 | 2026-07-25 |
Rapid recovery and functional resilience of bone marrow function post B-cell acute lymphoblastic leukemia
2026-07-23, Haematologica
IF:8.2Q1
DOI:10.3324/haematol.2025.300439
PMID:42489070
|
NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |